Kafue National Park is the largest national park in Zambia, covering an area of about 22,400 km2 (similar in size to Wales or Massachusetts). It is the second largest national park in Africa and is home to 152 different species of mammals. There are also 515 bird species, 70 reptile species, 58 species of fish and 36 amphibious species. 

The park is named for the Kafue River.  It stretches over three provinces: North Western, Central and Southern. The main access is via the Lusaka–Mongu Road from Lusaka to Mongu which crosses the park north of its centre. Seasonal dirt roads also link from Kalomo and Namwala in the south and south-east, and Kasempa in the north.